surmount-1 tirzepatide nejm percent weight loss 72 weeks SURMOUNT-1 (NEJM 2022) tested tirzepatide — a dual GIP/GLP-1 receptor agonist — in 2,539 adults with obesity and achieved up to 20.9% mean weight loss at the highest dose. 57% of participants
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New research from the SURPASS-EARLY trial found that tirzepatide improved glycemic control, body weight, and waist circumference over 104 weeks compared with intensified conventional care in adults with early type 2 diabetes.
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